2006 Mules Football Schedule
| Date | Opponent | Time |
| Sept. 2 | at Lincoln University (Jefferson City, Mo.)
 Game
NotesGame Broadcast - Listen / Download |
W, 78-0 (Recap) |
| Sept. 9 | vs. Dakota State University
Game
Notes Game Broadcast - Listen / Download |
W, 52-0 (Recap) |
| Sept. 16 | vs. Washburn University* (Family Weekend)
Game
Notes Game Broadcast - Listen / Download |
L, 14-10 (Recap) |
| Sept. 23 | at Truman State*
(Kirksville, Mo.)
Game
Notes Game Broadcast - Listen / Download |
L, 24-21 (Recap) |
| Sept. 30 | at
Fort Hays State
University* (Hays, Kan.)
Game Notes |
W,
37-14 (Recap) |
| Oct. 7 | vs. Missouri Western State University*
Game
Notes Game Broadcast - Listen / Download |
L, 30-20 (Recap) |
| Oct. 14 | vs. Southwest Baptist University* (Homecoming)
Game
Notes Game Broadcast - Listen / Download |
W, 49-24 (Recap) |
| Oct. 21 |
at Missouri Southern State University*
(Joplin, Mo.)
Game
Notes Game Broadcast - Listen / Download |
L, 31-26 |
| Oct. 28 | vs. Northwest Missouri State University*
Game
Notes Game Broadcast - Listen / Download |
L, 31-14 (Recap) |
| Nov. 4 | vs. Emporia State University*
Game
Notes Game Broadcast - Listen / Download |
W, 48-21 (Recap) |
| Nov. 11 | at Pittsburg State University * (Pittsburg, Kan.)
Game
Notes Game Broadcast - Listen / Download |
L, 35-30 |
*MIAA game / Home games in bold