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Biology and Agriculture

W.C. Morris Building
Room 306
Warrensburg, MO 64093
Dr. Fanson Kidwaro, Chair
Phone: 660-543-4933



<DanaTucker>

Dr. Dana TuckerDr. Dana Tucker

Assistant Professsor, Biology

Education

B.S., Biology, Missouri Southern State University
M.S., Cell and Molecular Biology, Missouri State University
PhD., Biochemistry, Cell and Developmental Biology, Emory University

Dr. Tucker currently teaches Biol 2510 Basic Genetics, Biol 2512 Cell Biology and Biol 5031 Biological Literature.

Research: Students interested in Research Projects please contact me.

The overarching goal of the Tucker research group is to reveal mechanisms involved in axon guidance using Caenorhabditis elegans (C. elegans) as a model organism. C. elegans are great for student-centered research projects because they are safe and amenable to a variety of genetic, molecular and cellular techniques. Their rapid life-cycle, hermaphroditic reproduction and high fecundity are also ideal for students who must schedule time in the lab around classes.

During the development of the nervous system, neurons encounter and interpret signals that direct the outgrowth and connections of axons and/or dendrites to their appropriate targets. Both long and short-range cues can act as attractants or repellents for growing axons and guide them in a spatial-temporal manner to create complex neural networks. In humans, aberrant axon guidance is associated with multiple, different neurological disorders. Mutations in genes encoding axon guidance proteins and receptors can cause congenital axon guidance disorders, for example midline crossing disorders, or contribute to the etiology multifactorial disorders such as epilepsy, schizophrenia, autism and Parkinson’s disease.

Although we have identified some of the genes and molecules associated with complex neurological disorders, major gaps in our knowledge lies in our lack of understanding how neurons form networks. I am interested in identifying combinatorial sets of genetic interactions responsible for axon guidance. Mapping the genetic pathways involved in neural circuit formation is necessary to gain a more complete understanding the pathology of these multifactorial diseases and could be key in diagnosing, managing and/or treating complex neurological disorders.

 

Department of Biology and Agriculture
Office: WCM 304
Phone: 660-543-8997
Email: dtucker@ucmo.edu